• br Methods The study protocol was approved by the

  2019-06-12

  

  Methods The study protocol was approved by the ethics committee at Juntendo University Nerima Hospital. After informed consent was obtained, SBC measurement was performed using a blood sample from each participant. Plasma was separated from each sample immediately after collection by centrifugati

• Introduction Multiple myeloma MM is

  2019-06-12

  

  Introduction Multiple myeloma (MM) is the most frequent cancer to involve the skeleton with 80–90% of patients developing bone lesions during their disease course [1]. Myeloma bone lesions are purely osteolytic and are associated with severe and debilitating bone pain, pathologic fractures, hyperca

• br Growth supportive characteristics of the BM

  2019-06-12

  

  Growth-supportive characteristics of the BM vascular niche Similar to normal tissues, tumours also need functional blood vessels to support their growth via the delivery of oxygen and nutrients. When a DTC starts proliferating into a micrometastasis, it drives angiogenesis to build new blood vess

• coelenterazine Before the start of the

  2019-06-12

  

  Before the start of the study, we expected referral of up to 3% visceral leishmaniasis cases to the tertiary hospital for management of eventual complications. However, no referral was necessary because all adverse events were mild. Incidence of adverse events was about 47% during treatment and 63%

• Esta idea se reforz con uno de

  2019-06-12

  

  Esta idea se reforzó con uno de los elementos identitarios oficiales de la organización, su propio escudo. La comil tomó cuatro de las características reconocibles del pgt histórico; es decir, las siglas, la estrella, la hoz y el martillo, y el círculo que enmarcó todos estos símbolos, mismos que de

• MCL has a poor long term

  2019-06-11

  

  MCL has a poor long-term response to current treatment strategies, for the most commonly used R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone), the remission rate is good (75–96%) but brief in duration. Despite the study of several other chemotherapy regimens

• En este exordio de la

  2019-06-11

  

  En este exordio de la carta, hoy perdida, que acompañaba la obra de Pané, se expresan todas las dudas del Almirante que, a pesar de la hipótesis de la ausencia de idolatría entre los taínos (interpretación esencial para ofrecer una representación de los indígenas que justificara su dominio), se most

• br We have reviewed the

  2019-06-11

  

  We have reviewed the issues and arguments presented by Wang et al. In fact, we have well-clarified these issues in “Discussion” section of our original article. The aim of our study was to investigate the expression of maternal antineuronal b-raf inhibitors and their role in childhood autism spe

• HF is associated with the down regulation

  2019-06-11

  

  HF is associated with the down-regulation of multiple potassium (K) currents (i.e., Ito, IKs, IKr, IK1, and IKATP). The only K channel that is upregulated in HF is the small conductance Ca-activated K (SK) channel. The SK channel was originally found in most neurons. The increase in Cai evoked by th

• One year after her initial

  2019-06-11

  

  One year after her initial diagnosis, the patient presented back for the abrupt onset of symmetrical bilateral lower-limb weakness and numbness. The patient did not report other symptoms or history of trauma. Clinical examination revealed a healthy person except for a symmetrical proximal and distal

• jasplakinolide A possible mechanism of the initiation of HST

  2019-06-11

  

  A possible mechanism of the jasplakinolide of HSTCL is a prolonged immunosuppressive status which generates the expansion of γδ T-cells recognizing multiple pathogens through excessive antigenic stimulation. Our cases did not have any previous illness related to immunosuppression, recurrent infecti

• Perhaps the greatest challenge however relates to

  2019-06-11

  

  Perhaps the greatest challenge however, relates to the epidemiology of this disease and understanding the interactions that occur between the reservoir hosts (ie, monkeys), vectors, and human activities that enable transmission. Understanding these complex behavioral and ecological interactions will

• pd0332991 But in comes the good news from

  2019-06-11

  

  But in comes the good news from these three NEOVITA studies: there are other effective, feasible interventions that can be implemented everywhere. Rajiv Bahl and colleagues identify that early initiation of breastfeeding and exclusive breastfeeding have independent beneficial effects on neonatal mo

• In addition we evaluated the left atrium

  2019-06-11

  

  In addition, we evaluated the left atrium–left ventricle contraction sequence caused by the interatrial conduction delay. When we performed AV sequential pacing using the nominal AV delay setting, left atrial contractions were significantly delayed and were almost simultaneous with the left ventricu

• angiotensin receptor blocker En conclusi n vivir bien buen v

  2019-06-10

  

  En conclusión, vivir bien/buen vivir no son por el momento nuevos paradigmas, pese a que, por ejemplo, los autores del Plan Nacional para el Buen Vivir de Ecuador (2009-2013) se referan a una transición del concepto de desarrollo al buen vivir en los términos de un “cambio de para-digma”. En estos t

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