• br Conflict of interest br Introduction Diabetes often

  2018-10-25

  

  Conflict of interest Introduction Diabetes, often referred as diabetes mellitus, describes a group of metabolic disorders characterized by common hyperglycaemia with disturbances of fat, carbohydrate and protein metabolism because of the defects in insulin releasing, insulin action, or both. A

• Since the first report of induced pluripotent

  2018-10-24

  

  Since the first report of induced pluripotent stem (iPS) PD 0332991 generated by the expression of four transcription factors Oct4, Sox2, Klf4 and c-Myc (OSKM) in fibroblasts (Takahashi and Yamanaka, 2006), there has been a variety of technical improvements to generate iPS cells more efficiently. D

• The presence of major differences among fibroblasts isolated

  2018-10-24

  

  The presence of major differences among fibroblasts isolated from various organs and tissues have been described several decades ago. Castor et al have described striking differences between fibroblasts from skin, periosteum, pericarpdium and synovial tissue in terms of proliferative potential, MLN0

• br Author contributions br Conflict of interests br

  2018-10-24

  

  Author contributions Conflict of interests Acknowledgments We thank Dr. Wenying Liu for her help with the initial setup of the electrospinning and Mr. Xiyu Li for his assistance with SEM. We also thank Emory Children\'s Pediatric Research Center Flow Cytometry Core and Animal Physiology Cor

• br Materials and methods br

  2018-10-24

  

  Materials and methods Results Discussion The role played by Nurr1 in the regulation of NPCs across several cisapride Supplier regions has been extensively investigated. It has been suggested that Nurr1 may exert a strong control on both the proliferation and differentiation of NPCs into ne

• Genetic manipulation by overexpression of exogenous factors

  2018-10-24

  

  Genetic manipulation by overexpression of exogenous factors such as Nanog, Klf2, and Prdm14 enables conversion of mouse EpiSCs to ESC-like cells (rESCs) (Gillich et al., 2012; Silva et al., 2009). Furthermore, transition of mouse EpiSCs to rESCs rarely occurs even after stimulation with LIF-STAT3 si

• Recently several clinical trials of stem cell based therapy

  2018-10-24

  

  Recently, several clinical trials of stem-cell-based therapy for SCI using either human NS/PCs (Cummings et al., 2005; Salazar et al., 2010) or human ESC-derived OPCs (Strauss, 2010) have been initiated. Compared with these stem cells, iPSCs raise fewer ethical concerns in certain countries (Nori et

• Based on these principles we speculated

  2018-10-24

  

  Based on these principles, we speculated that the use of rBC2LCN as a cargo of cytotoxic agent would provide an efficient strategy to eliminate hPSCs. Here we generated a recombinant lectin-toxin fusion protein by fusing rBC2LCN with 23 kDa of a catalytic domain of Pseudomonas aeruginosa exotoxin A

• Cryopreserved peripheral blood mononuclear cells PBMC from t

  2018-10-24

  

  Cryopreserved peripheral blood mononuclear cells (PBMC) from this patient were used for the generation of an induced pluripotent stem cell (iPSC) that harbour a “highest risk” RET mutation according to ATA guidelines, i.e. a 2753T>C missense de novo mutation at exon 16 leading to the most frequent M

• In a recent study Scheffer et al the expression of

  2018-10-24

  

  In a recent study (Scheffer et al., 2015), the expression of Lmod3 during natural mouse development was found to be restricted to cochlear HCs and that of Dnah5 to vestibular HCs, while double-positive cells were not produced. In the present study, immunocytochemical analyses showed that the cochlea

• In order to understand how hematopoiesis

  2018-10-24

  

  In order to understand how hematopoiesis is regulated, it is necessary not only to understand the different signals emanating from the niche (Anthony and Link, 2014), but also to comprehend the integration of these signals by HSCs. Canonical Wnt signaling has been related to the regulation of HSCs

• Using both standard RNA seq and RNA seq half

  2018-10-24

  

  Using both standard RNA-seq and RNA-seq carboxypeptidase analysis, we identified UPF1-regulated transcripts that are good candidates to be direct NMD targets in hESCs. There was considerable overlap between these candidate NMD target transcripts expressed in hESCs with previously identified high-co

• The results presented here are consistent with the propositi

  2018-10-24

  

  The results presented here are consistent with the proposition that the onset of cellular pathology in FTD occurs earlier than clinical manifestations, which has been corroborated by biomarker studies in Alzheimer’s disease (Jack et al., 2013). By implementing a panel of biochemical and cellular ass

• orexin The ensuing replication stress during rapid expansion

  2018-10-24

  

  The ensuing replication stress during rapid expansion elicits a broad DDR, when Fancd2-deficient HSPC accumulate DNA damage and activate p38 MAPK in response to physiological replication demands encountered during development. The lack of a more robust γH2AX phosphorylation seemed initially surprisi

• WRN and SNEVhPrp hPso are members of a DDR protein

  2018-10-24

  

  WRN and SNEVhPrp19/hPso4 are members of a DDR protein complex (Zhang et al., 2005) and are involved in adipogenesis of mouse 3T3-L1 ache inhibitor (Cho et al., 2007; Turaga et al., 2009). WRN is a helicase required for DNA recombination and repair and interacts with the SNEV complex during repair o

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