• Introduction The degree to which embryonic stem cells ESCs r

  2018-10-22

  

  Introduction The degree to which embryonic stem opioid receptors (ESCs) represent generic properties of pluripotent founder cells in mammalian embryos is unresolved (Nichols and Smith, 2012; Smith, 2001). Mouse ESCs are the paradigmatic model. However, it is increasingly clear that there are diffe

• br Results br Discussion Utilizing primary breast cancer

  2018-10-22

  

  Results Discussion Utilizing primary breast cancer tissue as well as primary xenografts and established cell lines, we demonstrate that BCSCs exist in distinct mesenchymal-like and epithelial-like states that can be identified by specific marker mitotic inhibitor and display distinct gene-expr

• It has been previously confirmed that

  2018-10-22

  

  It has been previously confirmed that SB-505124 selectively inhibits TGF-β and activin signaling more efficiently than its analog SB-431542 (DaCosta Byfield et al., 2004), which has been shown to induce neural differentiation when used in combination with Noggin (Chambers et al., 2009). IWP-2, on th

• br Experimental Procedures br Author Contributions br Introd

  2018-10-22

  

  Experimental Procedures Author Contributions Introduction Neural stem FMK (NSCs) are self-renewing, multipotent cells that have the capability to differentiate into neurons, astrocytes, and oligodendrocytes (Gage, 2000). NSCs are abundant during CNS development and also exist in the adult

• br Conclusions The following are the supplementary

  2018-10-22

  

  Conclusions The following are the supplementary data related to this article. Acknowledgments We thank Drs. Tomoki Todo and Nobuhito Saito of the University of Tokyo, Japan, for generously providing us with the TGS01 cells. This work was supported by Grants-in-Aid for Scientific Research, for

• So far literature on A R has been in

  2018-10-22

  

  So far, literature on A1R has been in favor of a prevailing role played by these receptors in the activation of osteoclasts (Kara et al., 2010; He and Cronstein, 2012) and some findings showed that the blockade of these AR may induce favorable effects on osteoporosis or fracture healing. However, ou

• In addition to EPDCs endogenous c kit cells have been

  2018-10-20

  

  In addition to EPDCs, endogenous c-kit+ Flavopiridol hydrochloride have been reported as cardiovascular progenitor cells capable of generating the three major cellular lineages of the heart (Beltrami et al., 2003; Ellison et al., 2013). Since the c-kit+ cardiovascular progenitor cells can be purifi

• In this study besides the high hits for

  2018-10-20

  

  In this study, besides the high hits for the evolutionarily hypervariable sites, we also noticed that certain mtDNA variants were shared by family members, pedigree-specific occurrence of mtDNA variants. This observation was unexpected but confirmed our previous speculation for a family-specific occ

• Despite the high degree of similarity between SCDSs and the

  2018-10-20

  

  Despite the high degree of similarity between SCDSs and the lack of strict segregation by function, we did identify genes that were highly over-represented by comparing 3 M-SCDSs and 3 F-SCDSs (see Supplementary Information for the role of these differentially expressed genes in skeletogenesis, oste

• kainic acid We next asked what the impact of culture induced

  2018-10-20

  

  We next asked what the impact of culture-induced senescence of the fibroblasts was on the reprogramming efficiency. Four representative fibroblast lines from young (ages and 1year) and old (ages 81 and 83year) donors were propagated for up to 25 passages (Fig. 2A). The pluripotent reprogramming effi

• The following are the supplementary

  2018-10-20

  

  The following are the supplementary data related to this article. Acknowledgment This work was supported by the DIR, NIDCR and NIAID of the IRP, NIH, DHHS. We thank the patients, healthy volunteers and clinical research staff for their contributions. Introduction The neurogenerative process

• mu agonist Using murine ESCs Correa Cerro et al screened the

  2018-10-20

  

  Using murine ESCs, Correa-Cerro et al. (2011) screened the effect of single overexpressed TFs from a panel of 137 transcription factors and selected for those which had the ability to induce a transcriptome shift towards specific lineages at 48h post induction. They followed that report by testing s

• br Materials and methods br Acknowledgements br

  2018-10-20

  

  Materials and methods Acknowledgements Resource table Resource details To generate the Saudi KACST induced Pluripotent Stem Cell line No 1 (SKiPSc1) cell line, four reprogramming Yamanaka factors (Oct3/4, Sox2, c-Myc, and Klf4) (Takahashi et al., 2007; Yu et al., 2007) were delivered to

• Human embryonic stem cells hESC provide an accessible

  2018-10-20

  

  Human embryonic stem AEG 3482 (hESC) provide an accessible platform for modeling cardiovascular differentiation in vitro, thus permitting the interrogation of signaling pathways that are specifically active in embryonic endothelium. Moreover, hESC-derived ECs can recapitulate fundamental cellular e

• br Materials methods The derivation and culturing conditions

  2018-10-20

  

  Materials & methods The derivation and culturing conditions of hAT-MSCs are thoroughly described in Supplementary Materials and methods section, while details regarding hiPS lines generation and validation are described elsewhere (Kyrkou et al., in press). Results Discussion Human AT-MSCs

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