• The compounds containing beryllium act as strong Lewis acids

  2024-02-01

  

  The compounds containing beryllium act as strong Lewis acids because of electron deficiency of the Be N-Acetylneuraminic acid mg []. Interactions of X-Be-Y compounds with different Lewis bases have been studied by Yanez and co-workers [], extensively. Recently, they proposed a class of extremely st

• br Antiangiogenic therapy in non small

  2024-01-31

  

  Antiangiogenic therapy in non-small cell lung cancer (NSCLC) Antiangiogenic targeted therapy is an area of active research in which numerous agents have been studied and have been shown to be effective for many tumor types including NSCLC. Angiogenesis is frequently upregulated in malignant solid

• br Experimental methods br Acknowledgments br Introduction L

  2024-01-31

  

  Experimental methods Acknowledgments Introduction Long-term potentiation (LTP) and long-term depression (LTD) at excitatory synapses are thought to underlie experience-dependent learning and memory. These synaptic plasticity mechanisms are best characterized at hippocampal CA1 synapses, whe

• Synthesis of the pterin carboxamides was

  2024-01-31

  

  Synthesis of the pterin-7-carboxamides was achieved, as shown in , based on a previously reported method that utilizes DBU as a key additive to dissolve pterin in organic solvents and accelerate the reaction., With this method, the pterin-amino RF 9 conjugates (–) were readily obtained by simply m

• A number of studies suggest that adiponectin

  2024-01-31

  

  A number of studies suggest that adiponectin promotes osteoblast differentiation and bone formation by directly targeting GSK-3β and β-Catenin signaling [64], [65], favoring bone marrow mesenchymal stem cell (BMSC) differentiation toward the osteoblastic lineage [66], [67], decreasing sympathetic to

• We aim to evaluate the AK

  2024-01-31

  

  We aim to evaluate the AK in regulating adenosine signaling in the retina. It was reported that the degree of SKL2001 injury directly depends on expression levels of AK and the resulting extracellular levels of adenosine (Boison, 2006). Indeed, transgenic mice overexpressing AK are highly susceptibl

• Although experiments on animals and cells indicate

  2024-01-30

  

  Although experiments on animals and cells indicate that antioxidant and free radical scavenging agents have protective effects against brain damage, the results of preclinical trials are not as encouraging. Edaravone is a type of free radical scavenging drug that was first used as a neuroprotective

• Of the many different types of

  2024-01-30

  

  Of the many different types of DNA lesions, DNA double strand breaks (DSBs) are amongst the most deleterious. It has been suggested that a single unrepaired DSB may be sufficient to induce cell death (Bennett et al., 1993), whereas misrepaired DSBs can result in loss of genetic information, potentia

• Introduction Initially postulated to represent the main

  2024-01-30

  

  Introduction Initially postulated to represent the main source of ATP production in eukaryotic cells, mitochondria are recently recognized to perform manifold essential functions beyond energy production, impacting most areas of cell biology and medicine [1]. Mitochondrial metabolism is both the ba

• To the best of our

  2024-01-30

  

  To the best of our knowledge, this is the first study documenting the SCC modulatory effect at central and kidney level on the shift in the vasoconstrictor-vasodilator ratio of mRNA expression of angiotensin receptors toward vasoconstriction in XY-SCC and/or vasodilation in XX-SCC mice. From these r

• Prostate cell growth and prostate carcinogenesis are not onl

  2024-01-30

  

  Prostate cell growth and prostate carcinogenesis are not only mediated by androgens, they are also dependent on functional insulin receptor (IR) and insulin-like growth factor-1 (IGF-1) receptor (IGF1R) signaling. Previous studies addressed this issue and reported a correlation between high insulin

• br Author Contributions br Acknowledgments br Introduction

  2024-01-30

  

  Author Contributions Acknowledgments Introduction Cerebral ischemia-reperfusion (I/R) injury is a pathological phenomenon that occurs after restoration of blood supply to BDA-366 sale tissues subsequent to ischemia or hypoxia (Carden and Granger, 2000). It typically occurs after therapeuti

• Phenyl sulfate australia br Introduction There are greater t

  2024-01-30

  

  Introduction There are greater than five million Americans living with Alzheimer's dementia and more than 35 million people worldwide [1], and without a way to stop or slow the progression, there will be nearly a tripling of individuals affected by 2050 (13.8 million) [1]. The urgency to develop

• The disease stimulatory effects of hyperadiponectinemia in

  2024-01-29

  

  The disease-stimulatory effects of hyperadiponectinemia in patients contradict a previous view based on studies of preclinical models showing that APN might be beneficial for AD [8]. Indeed, despite the action of APN as a risk factor in patients with AD, APN is protective against oxidative stress-in

• The major strength of this study is the large sample

  2024-01-29

  

  The major strength of this study is the large sample size which increases the statistical power to detect the likely subtle differences in peripheral methylation observed in psychiatric disorders (Olsson et al., 2010). Larger studies help provide more robust estimates of true associations, as small

16022 records 204/1069 page Previous Next First page 上5页 201202203204205 下5页 Last page