• In addition to gonadotropes GnRHRs have also been detected o

  2022-04-20

  

  In addition to gonadotropes, GnRHRs have also been detected on somatotropes, lactotropes, thyrotropes, melanotropes, somatolactin (SL) cells, and/or corticotropes using immunohistochemical, radioligand-binding, or mRNA expression approaches across species; including fishes, rats, and humans (La Rosa

• br Conclusion The wild study reports

  2022-04-20

  

  Conclusion The wild study reports seasonal variations in reproductive physiology, behavior and Cathepsin K Activity Fluorometric Assay Kit plasticity at different age stages in wild-caught Mongolian gerbils. The gerbils in breeding seasons have more mature sexual development, higher exploratory

• TXA has been shown to

  2022-04-20

  

  TXA has been shown to be a competitive antagonist on the GABAA receptor and potentially also the glycine [7], [12], [15] receptor. Furtmuller et al. showed that TXA right-shifted the GABA CRC by one order of magnitude [7], while in our study TXA similarly right-shifted the GABA EC50 value from 0.33 

• Besides the described effects on gross locomotor function im

  2022-04-19

  

  Besides the described effects on gross locomotor function, impairment of visuo-motor coordination and fine-motor skills like resting tremors, bradykinesia and rigidity were also investigated, reflecting on the symptomatology of Parkinson's disease in humans (Inzelberg et al., 2008). Preclinically, t

• br Materials and methods br Conflicts of interest Some of

  2022-04-19

  

  Materials and methods Conflicts of interest Some of the peptidomimetic compounds in this work are the subject of the patent application “Peptidomimetics for Imaging the Ghrelin Receptor”, WO/2016/191865 A1, December 8th, 2016. Acknowledgements Special thanks go to Rebecca McGirr (Lawson He

• Inhibitors of the G rdos effect include the Ca

  2022-04-19

  

  Inhibitors of the Gárdos effect include the Ca2+-channel blocker nitrendipine with an IC50 of ∼103nM (Ellory et al., 1992, Ellory et al., 1992); its mode of action is likely to be from direct blockage of K+ flux through the Gárdos channel (Ellory et al., 1992, Ellory et al., 1992), and the peptidic

• It has also been demonstrated that PS is ubiquitinated by

  2022-04-19

  

  It has also been demonstrated that PS1 is ubiquitinated by Caenorhabditis elegans SEL-10 [52], Fbw7 the mammalian homologue of SEL-10 [38], and more recently by tumour necrosis factor Vincristine associated factor 6 (TRAF6), which facilitates Lysine-63 (K63)-linked polyubiquitination of PS1 [50], [

• For functional metagenomics based gene screening

  2022-04-19

  

  For functional metagenomics-based gene screening, the DNA library construction approach is widely used . Fosmid and cosmid libraries are usually used to explore novel genes. Lee et al. reported that a halotolerant and protease-resistant α-galactosidase was identified from the gut metagenome of , a

• br Conclusion br Acknowledgements br Introduction Aminobutyr

  2022-04-19

  

  Conclusion Acknowledgements Introduction γ- Aminobutyric Neuregulin/Heregulin-1β (NRG-1β/HRG-1β), human recombinant protein synthesis (GABA) is the main inhibitory neurotransmitter in the adult central nervous system. GABA receptors are divided into two classes, GABAA and GABAB. GABAA is a

• In addition several other considerations were

  2022-04-19

  

  In addition, several other considerations were made for the optimization exercise. While the structural features of the endogenous ligands for long-chain fatty Melanocyte stimulating hormone release inhibiting factor receptors suggest obtaining orthosteric agonists with drug-like properties may be

• To date increasing evidence has demonstrated that dysregulat

  2022-04-19

  

  To date, increasing evidence has demonstrated that dysregulated lncRNAs are closely associated with the tumorigenesis and development of HCC via ceRNA modes [29,30]. LncRNAs could bind with special miRNAs and abrogate the inhibitory effect of these miRNAs on their targeted transcripts. For example,

• Hippo signaling is unique in

  2022-04-19

  

  Hippo signaling is unique in that it does not possess a cognate ligand and receptor system. Instead, numerous upstream sensors that monitor cell morphology, cell polarity, cell-cell contact, and mechanical stress impinge onto the Hippo pathway core kinases, MST, and LATS. This in turn indicates the

• Finally life expectancy was strongly reduced in STK deficien

  2022-04-19

  

  Finally, life expectancy was strongly reduced in STK4-deficient patients. Even in those patients who received haematopoietic stem cell transplantation, the majority of patients died due to transplantation-related complications, raising the question whether MST1 expressed in nonhaematopoietic tissue

• br Acknowledgement The work was supported

  2022-04-19

  

  6. Acknowledgement The work was supported by the NSFC through Grant Nos. 11535016 and 11475232. It was also supported by CAS. The authors thank their collaborators for beneficial discussions and enthusiastic supports in the simulations and calculations. Introduction Hypoxia-inducible factors

• We demonstrated that bilirubin the product of heme metabolis

  2022-04-19

  

  We demonstrated that bilirubin, the product of heme metabolism by HO-1, exerted a potent suppression of NADPH oxidase activity (Fig. 2B). Different from the down-regulation of NADPH oxidase subunit by HO-1 induction in macrophages [24], the protein levels of the NADPH oxidase subunits in vascular en

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