• In summary the work by Park et al

  2020-08-04

  

  In summary, the work by Park et al. (2017) provides a strong evidence for the role of DNA damage in normal aging. By uncovering the link between activation of DNA damage and metabolic decline Park et al. (2017) demonstrate that the consequences of unrepaired DNA breaks go beyond mutations but also a

• br STAR Methods br Author Contributions Z Z

  2020-08-04

  

  STAR★Methods Author Contributions Z.Z., H.G., and C.Y. conceived the project. C.Y. performed almost all experiments. H.G. performed all bioinformatics and statistical analysis. H.G. and J.H. performed some of the experiments. S.D. performed the in vitro DNA replication experiments under the gu

• br Discussion We show that in rad

  2020-08-04

  

  Discussion We show that in rad53-1 mutant cells, synthesis of leading and lagging strands is uncoupled, which leads to the exposure of long stretches of single-stranded leading-strand template coated with RPA under replication stress. We observed that the replicative DNA helicase, MCM, and associ

• NHS-12-Biotin DNA methylation is associated with transcripti

  2020-08-04

  

  DNA methylation is associated with transcriptional silencing of tumor suppressors or other genes important for normal cellular function and plays an important role in the development of cancer and other diseases (such as breast and colorectal cancers) [19]. DNA methyltransferases (MTases) are a fami

• The biological activity of Hypericum extracts should

  2020-08-04

  

  The biological activity of Hypericum extracts should not be exclusively explained based on the effects of the major compound because it may also include the response to other bioactive compounds present in smaller concentrations. Interaction between compounds (synergistic effect) present in the extr

• In this study EDC NHS crosslinked collagen

  2020-08-03

  

  In this study, EDC/NHS crosslinked collagen films were derivatised with VWFIIINle-containing THPs and the effect on VWF and DDR2 activity was examined. First, we investigated restoration of the binding of DDR2 and VWF A3. Cell behavior beyond simple binding was also investigated through DDR2 Danazol

• Recently pharmacological studies have revealed that natural

  2020-08-03

  

  Recently, pharmacological studies have revealed that natural compounds achieve increasing attention due to its high therapeutic effectiveness and low adverse effect, compared with the chemically synthesized compounds. Emodin is a kind of natural anthraquinone derivative enriched in traditional Chine

• br Conclusion While previously the

  2020-08-03

  

  Conclusion While previously the C:P ratio of OA was thought to be an important determinant of plant P uptake from OA (e.g. Takeda et al., 2009) we found that this was not the case. Alternatively, the proportion of P in OA that was orthophosphate gave a reasonable indication of the availability of

• br Experimental Procedures br Author Contributions br

  2020-08-03

  

  Experimental Procedures Author Contributions Acknowledgments Introduction In addition to the HLA region numerous other loci have shown association with type 1 diabetes risk [1], and susceptibility Bay 65-1942 HCl salt mg have been identified in many of these regions [2]. How these genes

• During antibody responses B cell migration is orchestrated

  2020-08-03

  

  During antibody responses, B cell migration is orchestrated to facilitate: (i) access to antigen; (ii) interactions with helper T cells; and (iii) homing to the specialized microenvironments that promote rapid or long-term antibody production. Naïve Calcipotriol patrol secondary lymphoid organs for

• Smoking leads to an acute increase

  2020-08-03

  

  Smoking leads to an acute increase in BP and heart rate, persisting for more than 15min after smoking one cigarette, as a consequence of a powerful stimulation of the sympathetic nervous system [23]. Studies using ambulatory BP monitoring (ABPM) have shown that smoking is a key correlate of masked h

• cGAS has a central role in

  2020-08-03

  

  cGAS has a central role in STING activation after DNA sensing, but it is unknown if most of the DNA sensors act independently or in cooperation with the cGAS-cGAMP pathway. This was addressed for IFI16 (Almine et al., 2017, Jønsson et al., 2017) and PQBP1 (Yoh et al., 2015) but remains to be tested

• Introduction Double strand break DSB is the most deleterious

  2020-08-03

  

  Introduction Double strand break (DSB) is the most deleterious damage that threats DNA integrity. This frequent damage arises from environmental stress like UV, chemical agents or ionizing radiations (IRs). Although environmental stress does not lead directly to DSB, it produces Triciribine austral

• Here we report the development of a

  2020-08-03

  

  Here we report the development of a new fluorescence intensity (FLINT), signal increase, high-throughput assay that measures the oxidation of L-DHO to -orotate by DHODH. In this reaction, the reducing equivalents from the oxidation of the L-DHO are transferred to the FMN, yielding the reduced enzyme

• A putative locus for both

  2020-07-31

  

  A putative locus for both the basal deficits in cued fear learning as well as its normalization by CP154,526 may be the serotonergic projections originating from the dorsal raphe nucleus that innervate several selinexor areas implicated in fear learning, including the central amygdala and hippocamp

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