• During antibody responses B cell migration is orchestrated

  2020-08-03

  

  During antibody responses, B cell migration is orchestrated to facilitate: (i) access to antigen; (ii) interactions with helper T cells; and (iii) homing to the specialized microenvironments that promote rapid or long-term antibody production. Naïve Calcipotriol patrol secondary lymphoid organs for

• Smoking leads to an acute increase

  2020-08-03

  

  Smoking leads to an acute increase in BP and heart rate, persisting for more than 15min after smoking one cigarette, as a consequence of a powerful stimulation of the sympathetic nervous system [23]. Studies using ambulatory BP monitoring (ABPM) have shown that smoking is a key correlate of masked h

• cGAS has a central role in

  2020-08-03

  

  cGAS has a central role in STING activation after DNA sensing, but it is unknown if most of the DNA sensors act independently or in cooperation with the cGAS-cGAMP pathway. This was addressed for IFI16 (Almine et al., 2017, Jønsson et al., 2017) and PQBP1 (Yoh et al., 2015) but remains to be tested

• Introduction Double strand break DSB is the most deleterious

  2020-08-03

  

  Introduction Double strand break (DSB) is the most deleterious damage that threats DNA integrity. This frequent damage arises from environmental stress like UV, chemical agents or ionizing radiations (IRs). Although environmental stress does not lead directly to DSB, it produces Triciribine austral

• Here we report the development of a

  2020-08-03

  

  Here we report the development of a new fluorescence intensity (FLINT), signal increase, high-throughput assay that measures the oxidation of L-DHO to -orotate by DHODH. In this reaction, the reducing equivalents from the oxidation of the L-DHO are transferred to the FMN, yielding the reduced enzyme

• A putative locus for both

  2020-07-31

  

  A putative locus for both the basal deficits in cued fear learning as well as its normalization by CP154,526 may be the serotonergic projections originating from the dorsal raphe nucleus that innervate several selinexor areas implicated in fear learning, including the central amygdala and hippocamp

• The PI K Akt and PKC

  2020-07-31

  

  The PI3K/Akt and PKC pathways are pivotal in neuronal survival, specifically through the induction of several pro-survival or anti-apoptotic genes, also via the inhibition of pro-apoptotic proteins. In a chain of events interconnected, the PI3K activation phosphorylates and upregulates the Akt. In c

• A similar phenomenon was observed in

  2020-07-31

  

  A similar phenomenon was observed in the current investigation. The disparate findings with regard to pretreatment and post-treatment with HJP272 suggest that very early inflammatory events are responsible for programming the lung for subsequent fibrosis. A single treatment with this ERA leads to l

• Consistent with our previous data showing that WNV

  2020-07-31

  

  Consistent with our previous data showing that WNV Eg101 infection does not induce significant eIF2a phosphorylation in BHK Cyclic di-GMP (Emara and Brinton, 2007), PKR phosphorylation was not significantly induced in rodent cells after infection with either WNV Eg101 or other “natural” lineage 1 o

• br Guidance of B cell localization by EBI br EBI

  2020-07-31

  

  Guidance of B cell localization by EBI2 EBI2 expression and B cell disease Although chemoattractant receptors of the GPR family play essential roles in coordinating the migration of lymphocytes for efficient responses against pathogens, their dysregulation can result in the initiation or prog

• V5 Epitope synthesis br Acknowledgments The authors wish to

  2020-07-31

  

  Acknowledgments The authors wish to thank Dr. Jung-Suk Choi for helpful discussions and critical reading of this manuscript. Research was funded by the Department of Defense (W81XWH-13-1-0238) to A.J.B. and a Dissertation Research Award (0010-1710-10 DDDSARI) provided by Cleveland State Universit

• br STAR Methods br Author Contributions Z Z

  2020-07-31

  

  STAR★Methods Author Contributions Z.Z., H.G., and C.Y. conceived the project. C.Y. performed almost all experiments. H.G. performed all bioinformatics and statistical analysis. H.G. and J.H. performed some of the experiments. S.D. performed the in vitro DNA replication experiments under the gu

• br Experimental br Conflict of interest br Acknowledgments T

  2020-07-31

  

  Experimental Conflict of interest Acknowledgments This research was supported by a grant from KRIBB Research Initiative Program and Technological Developing Scheme of Jilin Province of People\'s Republic of China (20150101225JC), and (2013G020). Plasma concentrations of triglycerides, v

• Orthologues of carotenoid dioxygenases used by humans to pro

  2020-07-30

  

  Orthologues of carotenoid dioxygenases, used by humans to produce retinal from beta-carotene, have previously been characterised from the cyanobacteria Synechocystis PCC 6803 and Nostoc PCC 7107 [[11], [12], [13], [14]]. These orthologues are able to convert beta-carotene and apo-8-carotenal into al

• br Wound healing is an evolutionarily conserved pathophysiol

  2020-07-30

  

  Wound healing is an evolutionarily conserved pathophysiological paradigm of fibrogenesis. The wound healing response to injury is known to trigger functional (i.e., proliferative) and phenotypic changes throughout the skin, with involvement of multiple cell types (e.g., fibroblasts, lymphocytes, e

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