• Cysteine protease activities have been suggested to be impor

  2020-04-01

  

  Cysteine protease activities have been suggested to be important for Giardia’s pathogenesis [[11], [12], [13],16,18,19,21,28,29,35]. Recently several giardial CPs were shown to be released during host cell interactions [9,10]. The three major released CPs have recently been shown to be involved in t

• Cells expressing the CDK S D mutant

  2020-04-01

  

  Cells expressing the CDK5 S47D mutant exhibit impaired migration and enhanced proliferation: Finally, we wished to determine the functional significance of this phosphoevent. Multiple studies have implicated active CDK5 in promotion of cell migration [9,16,[21], [22], [23], [24]] and in one study th

• The DNA damage response DDR is a cellular mechanism that

  2020-04-01

  

  The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as Apoptozole regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been recog

• br Acknowledgements This work was supported by a

  2020-04-01

  

  Acknowledgements This work was supported by a Grant for the Program for the Strategic Research Foundation at Private Universities S1101017 organized by the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan and JSPS KAKENHI Grant Numbers JP22560209 and JP5K05842. The

• Dgat mice however had less adipose tissue

  2020-04-01

  

  Dgat−/− mice, however, had less adipose tissue, as reflected by lower total fat pad weights and body triglyceride content. Because of these findings, we hypothesized that, although Dgat−/− mice could make triglycerides through non-DGAT pathway(s), their triglyceride synthesis capacity might not be e

• br Other Alterations in Triglyceride Metabolism

  2020-04-01

  

  Other Alterations in Triglyceride Metabolism in DGAT-Deficient Mice Consistent with the enzyme\'s ubiquitous expression pattern, DGAT deficiency also altered triglyceride metabolism in other tissues. For example, postpartum Dgat−/− female mice were unable to nurse their young owing to an absence

• Since free testosterone diffuses into

  2020-04-01

  

  Since free testosterone diffuses into a target organ [1], a remarkable increase in free testosterone in plasma is expected to enhance androgen response in target organs including the prostate. In fact, the results of the present study showed testosterone and DHT levels, and mRNA expression levels of

• In order to further evaluate cpt a function

  2020-04-01

  

  In order to further evaluate cpt1a function, we determined its tissue distribution in large yellow croaker. The mRNA levels of cpt1a were detected in all the tested tissues, but at varying levels. cpt1a mRNA expression was the highest in liver among different tissues, similar to reports in other fis

• In this study we have developed and investigated

  2020-03-31

  

  In this study we have developed and investigated three NADPH-regenerating fusion partners with two different enzyme systems: a BVMO and an ADH. With the exception of one fusion construct (StGDH with LbADH), all fusion Benzoylmesaconitine mg resulted in good soluble expression as well as fully funct

• Oleandrin receptor An increasing body of evidence demonstrat

  2020-03-31

  

  An increasing body of evidence demonstrates that MXC can cause neurobehavioral and neuropathological alterations [7]. In the brain, there are several steroidogenic enzymes, which are responsible for neurosteroid production. Neurosteroids are subsets of steroids that rapidly change neuronal excitabil

• The authors gratefully acknowledge financial support

  2020-03-31

  

  The authors gratefully acknowledge financial support from the State of São Paulo Research Foundation (FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo), grants 2013/07600-3 and 2013/25658-9, and the National Council for Scientific and Technological Development (CNPq, Conselho Nacional de

• CXC chemokines are primarily expressed in immune organs and

  2020-03-31

  

  CXC chemokines are primarily expressed in immune organs and the central nervous system: the mouse thymus and spleen (Heesen et al., 1996), chicken bursa (Liang et al., 2001), primate (Macaca mulatta) Dihydrodaidzein sale (Federsppiel et al., 1993) and cattle locus coeruleus, cerebellum and pons (Ri

• br Experimental section br Results br Discussion In our

  2020-03-31

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised Gemcitabine HCl receptor did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies i

• The majority of pro inflammatory cytokines are

  2020-03-31

  

  The majority of pro-inflammatory cytokines are regulated by NFκB, and recently, it has been found that p38 MAPK partly regulates NFκB-driven gene 2-D08 by increasing the association of the basal transcriptional factor, TATA-binding protein, with the C terminus of p65 subunit of NFκB and increasing t

• As expected the nortestosterone derived progestins tested we

  2020-03-31

  

  As expected, the 19-nortestosterone-derived progestins tested were moderate agonists of hAR (C), with EC50s ranging from 2 to 10nM, however all were less potent than the endogenous ligand DHT by at least a factor of 6, with relative potencies ranging from 0.0301 to 0.164. This is in agreement with p

16023 records 857/1069 page Previous Next First page 上5页 856857858859860 下5页 Last page