• At present there have been relatively few

  2020-01-13

  

  At present, there have been relatively few studies that evaluated potential correlations between pulmonary and pleura metastases, hilar and mediastinal Mitochondrial DNA Isolation Kit nodes, and organs associated with distant metastasis and EGFR mutations [33,34,37]. Further research on these relati

• In general cellular senescence is considered a programmed

  2020-01-13

  

  In general, cellular senescence is considered a programmed response to stress that can be activated by oxidative stress, irradiation or action of substances or drugs. These stressors cause DNA damage and, through the action of specific proteins (p53 and p21), lead to cell senescence (di Fagagna, 200

• Two key enzymes play important roles in the

  2020-01-13

  

  Two key enzymes play important roles in the bioconversion of xylitol from d-arabitol, namely d-arabitol dehydrogenase (ArDH) and NADH-dependent xylitol dehydrogenase (XDH), respectively (Qi et al., 2014). In an earlier study, we developed a high xylitol yield strain by expressing xdh in E. coli BL21

• Our structures also provide new insights into CRTH drug

  2020-01-13

  

  Our structures also provide new insights into CRTH2 drug development. The ligand binding pocket revealed by our structures comprises many aromatic residues and a few polar residues at the distal end. Correspondingly, most CRTH2 antagonists share a similar structural feature characterized by an acet

• Allele specific methylation has been observed in

  2020-01-13

  

  Allele-specific methylation has been observed in CpG islands of imprinted genes.27, 32 In the present study, however, methylation of CpG1 was specific to ALL Fmoc-Leu-OH synthesis and occurred in the leukemia cells of 28% of children with ALL, but it was not found in normal leukocytes from the same

• Despite many studies having demonstrated the

  2020-01-11

  

  Despite many studies having demonstrated the importance of connexin43 (Cx43), the most abundant connexin in bone cells, for bone development and turnover during the last decade [27], little is currently known about GJIC and Cx43 in primary bone tumors. In this report, we analyzed the specific role o

• MSCs are self renewing multipotent progenitor cells with mul

  2020-01-11

  

  MSCs are self-renewing, multipotent progenitor cells, with multilineage potential to differentiate into adipocytes, osteocytes, and chondrocytes. In addition, MSCs can migrate to sites of inflammation, supporting hematopoiesis and homeostatic maintenance. Given their unique therapeutic properties, M

• ER stress was monitored by both an increase of

  2020-01-11

  

  ER stress was monitored by both an increase of the ER chaperone (GRP78, GRP94) and the activation of the ER resident caspase-12. ER stress response (also known as the unfolded protein response) is a defense mechanism against various cellular stresses which causes accumulation of unfolded proteins in

• br Materials and methods br Statistical analysis All

  2020-01-11

  

  Materials and methods Statistical analysis All statistical analyses were performed using SPSS software version 20. Protein Erastin data of DNMTs and clinicopathological parameters were collected. Mann-Whitney U Test was used to assess the differential expression of nonparametric data of DNMTs

• Numerous studies have pointed to the DGAT reaction being cri

  2020-01-11

  

  Numerous studies have pointed to the DGAT reaction being critical for TAG assembly and in several cases it has been shown to limit carbon flux from lipid precursors towards TAG accumulation [12]. Thus, in Brassica napus, the DGAT substrate, diacylglycerol (DAG), accumulates during periods of rapid l

• Stable isotope studies applied to skeletal remains of early

  2020-01-11

  

  Stable isotope studies, applied to skeletal remains of early Pacific populations, have shown a trend toward a horticultural diet with temporal variation in response to local environmental conditions (Field et al., 2009; Kinaston and Buckley, 2013; Valentin et al., 2010, Valentin et al., 2014; Kinast

• The most common pathology associated with FGR is poor

  2020-01-11

  

  The most common pathology associated with FGR is poor placental perfusion as a result of abnormal placentation [4]. Placental developmental disorders and insufficient hormone synthesis may lead to FGR [5,6]. However, the exact mechanism responsible for abnormal placental development remains unclear.

• In this work we fabricated a

  2020-01-11

  

  In this work, we fabricated a kind of multifunctional nanoparticles, based on HAuNS coated by chitosan-stearic ahr inhibitor copolymer (CSO-SA), which was employed frequently to form micelles for hydrophobic drug delivery in our previous work [21], [22]. The nanoparticles can encapsulate DiR effici

• The hepatic cytochrome P CYP superfamily is essential

  2020-01-11

  

  The hepatic cytochrome P450 (CYP450) superfamily is essential for metabolising foreign chemicals, fatty acids, vitamins, hormones and other compounds and consists of 18 subfamilies (Uno et al., 2012). The number of discovered CYP genes is increasing as a result of intense work with CYP450 gene struc

• In addition to cleaving ubiquitins off

  2020-01-11

  

  In addition to cleaving ubiquitins off modified proteins, DUBs can also cleave between ubiquitin moieties within a polyubiquitin chain to edit the ubiquitin signal. DUBs employ different strategies to recognize polyubiquitin (Figure 1). DUBs that rely only on interactions on the S1 site tend to be A

15957 records 892/1064 page Previous Next First page 上5页 891892893894895 下5页 Last page